Cardiomyocytes overexpressing TNF‐α attract migration of embryonic stem cells via activation of p38 and c‐Jun amino‐terminal kinase

@article{Chen2003CardiomyocytesOT,
  title={Cardiomyocytes overexpressing TNF‐α attract migration of embryonic stem cells via activation of p38 and c‐Jun amino‐terminal kinase},
  author={Y. Chen and Q. Ke and Y. Yang and J. Rana and J. Tang and J. Morgan and Y. Xiao},
  journal={The FASEB Journal},
  year={2003},
  volume={17},
  pages={2231 - 2239}
}
  • Y. Chen, Q. Ke, +4 authors Y. Xiao
  • Published 2003
  • Medicine, Biology
  • The FASEB Journal
  • Tumor necrosis factor‐α (TNF‐α) plays an important role in the pathogenesis of myocardial infarction. Stem cells are able to regenerate infarcted myocardium. This study investigated whether TNF‐α was able to induce migration of embryonic stem cells (ESCs) in vitro. We used a Transwell assay in which neonatal rat cardiomyocytes, with or without transfection of TNF‐α cDNA, were plated in the lower compart‐ ments and mouse ESCs tagged with green fuorescent protein were added to the upper… CONTINUE READING
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