Cardiomyocyte-specific prolyl-4-hydroxylase domain 2 knock out protects from acute myocardial ischemic injury.

@article{Hoelscher2011CardiomyocytespecificPD,
  title={Cardiomyocyte-specific prolyl-4-hydroxylase domain 2 knock out protects from acute myocardial ischemic injury.},
  author={Marion Hoelscher and Monique Silter and Sabine Krull and Melanie von Ahlen and Amke Hesse and P. Schwartz and Ben Wielockx and Georg Breier and D{\"o}rthe Magdalena Katschinski and Anke Zieseniss},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 13},
  pages={11185-94}
}
Prolylhydroxylase domain proteins (PHD) are cellular oxygen-sensing molecules that regulate the stability of the α-subunit of the transcription factor hypoxia inducible factor (HIF)-1. HIF-1 affects cardiac development as well as adaptation of the heart toward increased pressure overload or myocardial infarction. We have disrupted PHD2 in cardiomyocytes (cPhd (-/-)) using Phd2(flox/flox) mice in combination with MLCvCre mice, which resulted in HIF-1α stabilization and activation of HIF target… CONTINUE READING