Cardiomyocyte-specific overexpression of human stem cell factor improves cardiac function and survival after myocardial infarction in mice.

@article{Xiang2009CardiomyocytespecificOO,
  title={Cardiomyocyte-specific overexpression of human stem cell factor improves cardiac function and survival after myocardial infarction in mice.},
  author={Fu-li Xiang and Xiangru Lu and Lamis Hammoud and Ping Zhu and Peter Chidiac and Jeffrey Robbins and Qingping Feng},
  journal={Circulation},
  year={2009},
  volume={120 12},
  pages={
          1065-74, 9 p following 1074
        }
}
BACKGROUND Soluble stem cell factor (SCF) has been shown to mobilize bone marrow stem cells and improve cardiac repair after myocardial infarction (MI). However, the effect of membrane-associated SCF on cardiac remodeling after MI is not known. The present study investigated the effects of cardiomyocyte-specific overexpression of the membrane-associated isoform of human SCF (hSCF) on cardiac function after MI. METHODS AND RESULTS A novel mouse model with tetracycline-inducible and cardiac… CONTINUE READING

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