Cardiomyocyte-specific inactivation of thyroid hormone in pathologic ventricular hypertrophy: an adaptative response or part of the problem?

@inproceedings{Pol2008CardiomyocytespecificIO,
  title={Cardiomyocyte-specific inactivation of thyroid hormone in pathologic ventricular hypertrophy: an adaptative response or part of the problem?},
  author={Christine J. Pol and Alice Muller and Warner S. Simonides},
  booktitle={Heart Failure Reviews},
  year={2008}
}
Recent studies in various rodent models of pathologic ventricular hypertrophy report the re-expression of deiodinase type 3 (D3) in cardiomyocytes. D3 inactivates thyroid hormone (T3) and is mainly expressed in tissues during development. The stimulation of D3 activity in ventricular hypertrophy and subsequent heart failure is associated with severe impairment of cardiac T3 signaling. Hypoxia-induced signaling appears to drive D3 expression in the hypertrophic cardiomyocyte, but other signaling… CONTINUE READING

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Left ventricular myocardial infarction in mice induces sustained cardiac deiodinase type III activity

  • CJ Pol, MJ Zuidwijk, E Deel
  • J Mol Cell Cardiol
  • 2008
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