Cardiomyocyte-restricted restoration of nitric oxide synthase 3 attenuates left ventricular remodeling after chronic pressure overload.

@article{Buys2007CardiomyocyterestrictedRO,
  title={Cardiomyocyte-restricted restoration of nitric oxide synthase 3 attenuates left ventricular remodeling after chronic pressure overload.},
  author={Emmanuel S Buys and Michael J. Raher and Sarah L Blake and Tomas G. Neilan and Amanda Graveline and Jonathan J. Passeri and Miguel {\'A}ngel Noceda Llano and T. Perez-Sanz and Fumito Ichinose and Stefan P. Janssens and Warren M. Zapol and Michael H Picard and Kenneth D. Bloch and Marielle Scherrer-Crosbie},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2007},
  volume={293 1},
  pages={
          H620-7
        }
}
Although nitric oxide synthase (NOS)3 is implicated as an important modulator of left ventricular (LV) remodeling, its role in the cardiac response to chronic pressure overload is controversial. We examined whether selective restoration of NOS3 to the hearts of NOS3-deficient mice would modulate the LV remodeling response to transverse aortic constriction (TAC). LV structure and function were compared at baseline and after TAC in NOS3-deficient (NOS3(-/-)) mice and NOS3(-/-) mice carrying a… CONTINUE READING
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