Cardiomyocyte-restricted overexpression of endothelial nitric oxide synthase (NOS3) attenuates beta-adrenergic stimulation and reinforces vagal inhibition of cardiac contraction.

Abstract

BACKGROUND In the heart, nitric oxide synthases (NOS) modulate cardiac contraction in an isoform-specific manner, which is critically dependent on their cellular and subcellular localization. Defective NO production by NOS3 (endothelial NOS [eNOS]) in the failing heart may precipitate cardiac failure, which could be reversed by overexpression of NOS3 in the… (More)

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Cite this paper

@article{Massion2004CardiomyocyterestrictedOO, title={Cardiomyocyte-restricted overexpression of endothelial nitric oxide synthase (NOS3) attenuates beta-adrenergic stimulation and reinforces vagal inhibition of cardiac contraction.}, author={Paul Massion and Chantal Dessy and F. Desjardins and Michel Pelat and Xavier Havaux and Catharina Belge and Pierre Moulin and Yves Guiot and Olivier Feron and Stefan Janssens and Jean-Luc. Balligand}, journal={Circulation}, year={2004}, volume={110 17}, pages={2666-72} }