Cardiomyocyte proliferation in cardiac development and regeneration: a guide to methodologies and interpretations.

@article{Leone2015CardiomyocytePI,
  title={Cardiomyocyte proliferation in cardiac development and regeneration: a guide to methodologies and interpretations.},
  author={Marina Leone and Ajit Magadum and Felix B. Engel},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2015},
  volume={309 8},
  pages={H1237-50}
}
The newt and the zebrafish have the ability to regenerate many of their tissues and organs including the heart. Thus, a major goal in experimental medicine is to elucidate the molecular mechanisms underlying the regenerative capacity of these species. A wide variety of experiments have demonstrated that naturally occurring heart regeneration relies on cardiomyocyte proliferation. Thus, major efforts have been invested to induce proliferation of mammalian cardiomyocytes in order to improve… CONTINUE READING

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