Cardiomyocyte proliferation and progenitor cell recruitment underlie therapeutic regeneration after myocardial infarction in the adult mouse heart

@inproceedings{Malliaras2013CardiomyocytePA,
  title={Cardiomyocyte proliferation and progenitor cell recruitment underlie therapeutic regeneration after myocardial infarction in the adult mouse heart},
  author={Konstantinos G Malliaras and Yiqiang Zhang and Jeffrey E. Seinfeld and Giselle Galang and E Tseliou and Ke Cheng and Baiming Sun and Mohammad Aminzadeh and Eduardo Marb{\'a}n},
  booktitle={EMBO molecular medicine},
  year={2013}
}
Cardiosphere-derived cells (CDCs) have been shown to regenerate infarcted myocardium in patients after myocardial infarction (MI). However, whether the cells of the newly formed myocardium originate from the proliferation of adult cardiomyocytes or from the differentiation of endogenous stem cells remains unknown. Using genetic fate mapping to mark resident myocytes in combination with long-term BrdU pulsing, we investigated the origins of postnatal cardiomyogenesis in the normal, infarcted and… CONTINUE READING
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