Cardiomyocyte lipotoxicity is mediated by Il-6 and causes down-regulation of PPARs.

@article{Haffar2015CardiomyocyteLI,
  title={Cardiomyocyte lipotoxicity is mediated by Il-6 and causes down-regulation of PPARs.},
  author={Taha Haffar and F{\'e}lix-Antoine B{\'e}rub{\'e}-Simard and Nicolas Bousette},
  journal={Biochemical and biophysical research communications},
  year={2015},
  volume={459 1},
  pages={54-9}
}
Here we sought to evaluate the effect of palmitate on cytokine and PPAR activity/expression. We investigated the effect of BSA conjugated palmitate and oleate on PPAR activity, PPAR-α and δ expression, as well as the expression of cytokines and key factors responsible for β-oxidation by qRT-PCR and western blotting in primary rat neonatal cardiomyocytes (NCMs). Furthermore we evaluated the effect of anti-inflammatory actions of AICAR and PPAR agonists on cytokine expression and cell death in… CONTINUE READING

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