Cardiomyocyte growth and sarcomerogenesis at the intercalated disc

  title={Cardiomyocyte growth and sarcomerogenesis at the intercalated disc},
  author={Amanda J. Wilson and Roman Schoenauer and Elisabeth Ehler and Irina Agarkova and Pauline M Bennett},
  booktitle={Cellular and Molecular Life Sciences},
Cardiomyocytes grow during heart maturation or disease-related cardiac remodeling. We present evidence that the intercalated disc (ID) is integral to both longitudinal and lateral growth: increases in width are accommodated by lateral extension of the plicate tread regions and increases in length by sarcomere insertion within the ID. At the margin between myofibril and the folded membrane of the ID lies a transitional junction through which the thin filaments from the last sarcomere run to the… CONTINUE READING
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