Cardiomyocyte expression of a polyglutamine preamyloid oligomer causes heart failure.

Abstract

BACKGROUND To determine whether soluble preamyloid oligomers (PAOs) are toxic when expressed internally in the cardiomyocyte, we tested the hypothesis that cardiomyocyte-restricted expression and accumulation of a known PAO is cytotoxic and sufficient to cause heart failure. METHODS AND RESULTS Intracellular PAOs, the entities believed to cause toxicity… (More)
DOI: 10.1161/CIRCULATIONAHA.107.750232

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