Cardiomyocyte degeneration with calpain deficiency reveals a critical role in protein homeostasis.

@article{Glvez2007CardiomyocyteDW,
  title={Cardiomyocyte degeneration with calpain deficiency reveals a critical role in protein homeostasis.},
  author={A Santana G{\'a}lvez and Abhinav Diwan and Amy M. Odley and Harvey S. Hahn and Hanna E Osinska and Jaime Melendez and Jeffrey Robbins and Roy A. Lynch and Yehia M A-H Marreez and Gerald W. Dorn},
  journal={Circulation research},
  year={2007},
  volume={100 7},
  pages={
          1071-8
        }
}
Regulating the balance between synthesis and proteasomal degradation of cellular proteins is essential for tissue growth and maintenance, but the critical pathways regulating protein ubiquitination and degradation are incompletely defined. Although participation of calpain calcium-activated proteases in post-necrotic myocardial autolysis is well characterized, their importance in homeostatic turnover of normal cardiac tissue is controversial. Hence, we evaluated the consequences of physiologic… CONTINUE READING

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