Cardiomyocyte cell cycle control and growth estimation in vivo--an analysis based on cardiomyocyte nuclei.

@article{Walsh2010CardiomyocyteCC,
  title={Cardiomyocyte cell cycle control and growth estimation in vivo--an analysis based on cardiomyocyte nuclei.},
  author={Stuart Walsh and Annica Pont{\'e}n and Bernd K Fleischmann and Stefan Jovinge},
  journal={Cardiovascular research},
  year={2010},
  volume={86 3},
  pages={365-73}
}
AIMS Adult mammalian cardiomyocytes are traditionally viewed as being permanently withdrawn from the cell cycle. Whereas some groups have reported none, others have reported extensive mitosis in adult myocardium under steady-state conditions. Recently, a highly specific assay of 14C dating in humans has suggested a continuous generation of cardiomyocytes in the adult, albeit at a very low rate. Mice represent the most commonly used animal model for these studies, but their short lifespan makes… CONTINUE READING

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