Cardiomyocyte apoptotic cell death in arterial hypertension: mechanisms and potential management.

  title={Cardiomyocyte apoptotic cell death in arterial hypertension: mechanisms and potential management.},
  author={Mar{\'i}a Antonia Fortu{\~n}o and Susana Ravassa and Ana Fortu{\~n}o and Guillermo Zalba and J M Olivares D{\'i}ez},
  volume={38 6},
Hypertensive heart disease is a progressive condition in which the compensatory left ventricular hypertrophy that maintains cardiac output leads to myocardial remodeling, characterized by fibrosis, insufficient vascularization, and alterations in cardiomyocytes, including contractile disturbances, changes in gene expression, and decrease in the number of cells. Structural abnormalities in the myocardial wall accelerate the development of diastolic and systolic dysfunction, resulting in heart… CONTINUE READING


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