Cardiomyocyte apoptosis induced by Galphaq signaling is mediated by permeability transition pore formation and activation of the mitochondrial death pathway.

@article{Adams2000CardiomyocyteAI,
  title={Cardiomyocyte apoptosis induced by Galphaq signaling is mediated by permeability transition pore formation and activation of the mitochondrial death pathway.},
  author={John W. Adams and A L Pagel and Christopher Kable Means and Donna Oksenberg and Robert C. Armstrong and Joan Brown},
  journal={Circulation research},
  year={2000},
  volume={87 12},
  pages={1180-7}
}
Expression of the wild-type alpha subunit of Gq stimulates phospholipase C and induces hypertrophy in cardiomyocytes. Addition of Gq-coupled receptor agonists additionally activates phospholipase C, as does expression of a constitutively active mutant form of Galphaq. Under these conditions, hypertrophy is rapidly succeeded by apoptotic cellular and molecular changes, including myofilament disorganization, loss of mitochondrial membrane potential, alterations in Bcl-2 family protein levels, DNA… CONTINUE READING
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