Cardiomyocyte-Specific BMAL1 Plays Critical Roles in Metabolism, Signaling, and Maintenance of Contractile Function of the Heart

  title={Cardiomyocyte-Specific BMAL1 Plays Critical Roles in Metabolism, Signaling, and Maintenance of Contractile Function of the Heart},
  author={Martin E. Young and Rachel A. Brewer and Rodrigo Antonio Peliciari-Garcia and Helen E Collins and Lan He and Tana L. Birky and Bradley W. Peden and Emily Thompson and Billy-Joe Ammons and Molly S. Bray and John C. Chatham and Adam R. Wende and Qinglin Yang and C W Chow and Tami A Martino and Karen L. Gamble},
  journal={Journal of Biological Rhythms},
  pages={257 - 276}
Circadian clocks are cell autonomous, transcriptionally based, molecular mechanisms that confer the selective advantage of anticipation, enabling cells/organs to respond to environmental factors in a temporally appropriate manner. Critical to circadian clock function are 2 transcription factors, CLOCK and BMAL1. The purpose of the present study was to reveal novel physiologic functions of BMAL1 in the heart, as well as to determine the pathologic consequences of chronic disruption of this… 

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