Cardiomyocyte Progenitor Cells as a Functional Gene Delivery Vehicle for Long-Term Biological Pacing

@inproceedings{Vgh2019CardiomyocytePC,
  title={Cardiomyocyte Progenitor Cells as a Functional Gene Delivery Vehicle for Long-Term Biological Pacing},
  author={Anna Maria Dorothea V{\'e}gh and A. D{\'e}nise den Haan and Luc{\'i}a C{\'o}cera Ortega and Arie O. Verkerk and Joost Petrus Geradus Sluijter and Diane Bakker and Shirley C. M. van Amersfoorth and Toon A. B. van Veen and Mischa Klerk and Jurgen Seppen and Jacques M. T. de Bakker and Vincent M Christoffels and Dirk Geerts and Marie Jose T. H. Goumans and Hanno L. Tan and Gerard J. J. Boink},
  booktitle={Molecules},
  year={2019}
}
Sustained pacemaker function is a challenge in biological pacemaker engineering. Human cardiomyocyte progenitor cells (CMPCs) have exhibited extended survival in the heart after transplantation. We studied whether lentivirally transduced CMPCs that express the pacemaker current If (encoded by HCN4) can be used as functional gene delivery vehicle in biological pacing. Human CMPCs were isolated from fetal hearts using magnetic beads coated with Sca-1 antibody, cultured in nondifferentiating… CONTINUE READING
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