Cardiomyocyte Ogt limits ventricular dysfunction in mice following pressure overload without affecting hypertrophy

@article{Dassanayaka2017CardiomyocyteOL,
  title={Cardiomyocyte Ogt limits ventricular dysfunction in mice following pressure overload without affecting hypertrophy},
  author={Sujith Dassanayaka and Robert Eli Brainard and Lewis Watson and Bethany W. Long and Kenneth R. Brittian and Angelica M. DeMartino and Allison L. Aird and Anna M. Gumpert and Timothy N. Audam and Peter J. Kilfoil and Senthilkumar Muthusamy and Tariq Parwaiz Hamid and Sumanth D. Prabhu and Steven P Jones},
  journal={Basic Research in Cardiology},
  year={2017},
  volume={112},
  pages={1-17}
}
The myocardial response to pressure overload involves coordination of multiple transcriptional, posttranscriptional, and metabolic cues. The previous studies show that one such metabolic cue, O-GlcNAc, is elevated in the pressure-overloaded heart, and the increase in O-GlcNAcylation is required for cardiomyocyte hypertrophy in vitro. Yet, it is not clear… CONTINUE READING