Cardiomyocyte ATP release through pannexin 1 aids in early fibroblast activation.

  title={Cardiomyocyte ATP release through pannexin 1 aids in early fibroblast activation.},
  author={Elena V Dolmatova and Gaelle Spagnol and Daniela Boassa and Jennifer R. Baum and Kimberly J Keith and Cinzia Ambrosi and Maria I Kontaridis and Paul L Sorgen and Gina E. Sosinsky and Heather S. Duffy},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={303 10},
Fibrosis following myocardial infarction is associated with increases in arrhythmias and sudden cardiac death. Initial steps in the development of fibrosis are not clear; however, it is likely that cardiac fibroblasts play an important role. In immune cells, ATP release from pannexin 1 (Panx1) channels acts as a paracrine signal initiating activation of innate immunity. ATP has been shown in noncardiac systems to initiate fibroblast activation. Therefore, we propose that ATP release through… CONTINUE READING
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