Cardiomyoblast-like cells differentiated from human adipose tissue-derived mesenchymal stem cells improve left ventricular dysfunction and survival in a rat myocardial infarction model.

@article{Okura2010CardiomyoblastlikeCD,
  title={Cardiomyoblast-like cells differentiated from human adipose tissue-derived mesenchymal stem cells improve left ventricular dysfunction and survival in a rat myocardial infarction model.},
  author={Hanayuki Okura and Akifumi Matsuyama and Chun-Man Lee and Ayami Saga and Aya Kakuta-Yamamoto and Anna Nagao and Nagako Sougawa and Naosumi Sekiya and Kazuhiro Takekita and Yashuhiro Shudo and Shigeru Miyagawa and Hiroshi Komoda and T. Okano and Yoshiki Sawa},
  journal={Tissue engineering. Part C, Methods},
  year={2010},
  volume={16 3},
  pages={417-25}
}
Adipose tissue-derived mesenchymal stem cells (ADMSCs) are multipotent cells. Here we examined whether human ADMSCs (hADMSCs) could differentiate into cardiomyoblast-like cells (CLCs) by induction with dimethylsulfoxide and whether the cells would be utilized to treat cardiac dysfunction. Dimethylsulfoxide induced the expression of various cardiac markers in hADMSCs, such as alpha-cardiac actin, cardiac myosin light chain, and myosin heavy chain; none of which were detected in noncommitted… CONTINUE READING