Cardiolipin synthase of Arabidopsis thaliana

@article{Nowicki2005CardiolipinSO,
  title={Cardiolipin synthase of Arabidopsis thaliana},
  author={Marcin Nowicki and Frank W. M{\"u}ller and Margrit Frentzen},
  journal={FEBS Letters},
  year={2005},
  volume={579}
}
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60 Citations
Highly Influential Citations
4
Background Citations
25
Methods Citations
4

60 Citations

T-DNA Insertion in the CLS Gene for Cardiolipin Synthase Affects Development of Arabidopsis thaliana

It is demonstrated that CLS plays important roles in development of A. thaliana, presumably due to the biosynthesis of CL in the mitochondria, through introduction of CLS into the mutants.

Identification and characterization of human cardiolipin synthase

A Eukaryote-like Cardiolipin Synthase Is Present in Streptomyces coelicolor and in Most Actinobacteria*

This is the first time that a CDP-alcohol phosphatidyltransferase from bacteria is shown to be responsible for CL formation and the broad occurrence of putative orthologues of Sco1389 among the actinobacteria suggests that CL synthesis involving a eukaryotic type Cls is common in actinOBacteria.

The Importance of Cardiolipin Synthase for Mitochondrial Ultrastructure, Respiratory Function, Plant Development, and Stress Responses in Arabidopsis[W]

This study characterize a cls mutant in Arabidopsis thaliana, which is devoid of CL, and shows that CLS is crucial for correct mitochondrial function and development inArabidopsis under both optimal and stress conditions.

Schizosaccharomyces pombe cardiolipin synthase is part of a mitochondrial fusion protein regulated by intron retention.

Cardiolipin at the heart of stress response across kingdoms

These studies showed that cardiolipin is not only important for mitochondrial ultrastructure and for the stability of respiratory complexes, but it is also a key player in the response to stress, the formation of reactive oxygen species, and the execution of programmed cell death.

Molecular species composition of plant cardiolipin determined by liquid chromatography mass spectrometry

During phosphate deprivation or exposure to an extended dark period, the amount of CL decreased in Arabidopsis, accompanied with an increased degree in unsaturation, suggesting the mechanism of CL remodeling during stress, and the function of highly unsaturated CL molecular species, remains to be defined.

Cardiolipin-Mediated Mitochondrial Dynamics and Stress Response in Arabidopsis[C][W]

This work reveals aspects of the properties and function of the phospholipid cardiolipin (CL) and uncovered conserved and plant-specific aspects of CL biology in mitochondrial dynamics and the organism response to environmental stresses.

Cardiolipin synthesis for the assembly of bacterial and mitochondrial membranes.

  • M. Schlame
  • Biology, Chemistry
    Journal of lipid research
  • 2008
It is shown that mitochondria produce cardiolipin species with a high degree of structural uniformity and molecular symmetry, among which there is often a dominant form with four identical acyl chains.

Mammalian cardiolipin biosynthesis.

...

References

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Phosphatidylglycerophosphate synthases from Arabidopsis thaliana

Identification of an Arabidopsis thaliana gene for cardiolipin synthase located in mitochondria

Cardiolipin synthase from Escherichia coli.

  • B. Tropp
  • Biology
    Biochimica et biophysica acta
  • 1997

Biosynthesis of Cardiolipin in Plant Mitochondria

Direct evidence is presented that the enzyme utilizes CDP-diacylglycerol in addition to phosphatidyl glycerol for the synthesis of cardiolipin.

The effects of phosphoglycerides on Escherichia coli cardiolipin synthase.

Isolation and Characterization of the Gene (CLS1) Encoding Cardiolipin Synthase in Saccharomyces cerevisiae *

Using homology searches for genes potentially encoding phospholipid biosynthetic enzymes, this work cloned the gene (CLS1) encoding CL synthase in Saccharomyces cerevisiae and definitively identifies the gene encoding theCL synthase of yeast.

Biochemical characterization and regulation of cardiolipin synthase in Saccharomyces cerevisiae.

Cardiolipin synthase expression is essential for growth at elevated temperature and is regulated by factors affecting mitochondrial development

CRD1 expression is controlled by factors affecting mitochondrial development, but not by the phospholipid precursors inositol and choline, suggesting that either CL or Crd1p is required for an essential cellular function.

Cardiolipin Synthase Is Associated with a Large Complex in Yeast Mitochondria*

It is concluded that yeast CL synthase is a 28-kDa protein, which forms an oligomeric complex whose biogenesis and/or activity is influenced by the assembly of cytochrome oxidase.

Arabidopsis phosphatidylglycerophosphate synthase 1 is essential for chloroplast differentiation, but is dispensable for mitochondrial function.

Genetic dissection of the lipid bilayer composition provides essential in vivo evidence for the role of individual lipid species in membrane function. To understand the in vivo role of the anionic…