Cardiolipin synthase of Arabidopsis thaliana

@article{Nowicki2005CardiolipinSO,
  title={Cardiolipin synthase of Arabidopsis thaliana},
  author={Marcin Nowicki and Frank W. M{\"u}ller and Margrit Frentzen},
  journal={FEBS Letters},
  year={2005},
  volume={579}
}
Functional expression studies in microorganisms showed that the Arabidopsis thaliana gene At4g04870 represents the cardiolipin synthase (CLS) gene encoding a hydrophobic preprotein of 38 kDa with a cleavable signal peptide for the import into mitochondria. CLS of Arabidopsis over‐expressed in Escherichia coli has an alkaline pH optimum, a strict requirement for divalent cations and a distinctly lower K m for cytidinediphosphate‐diacylglycerol than for phosphatidylglycerol. It displayed a… Expand
Identification and characterization of human cardiolipin synthase
TLDR
A human candidate gene/cDNA for cardiolipin synthase is identified, C20orf155, which appears to have a different substrate preference for cytidinediphosphate‐diacylglycerol species when compared to phosphatidylglycerl species and the possible implications for CL synthesis and remodeling are discussed. Expand
A Eukaryote-like Cardiolipin Synthase Is Present in Streptomyces coelicolor and in Most Actinobacteria*
TLDR
This is the first time that a CDP-alcohol phosphatidyltransferase from bacteria is shown to be responsible for CL formation and the broad occurrence of putative orthologues of Sco1389 among the actinobacteria suggests that CL synthesis involving a eukaryotic type Cls is common in actinOBacteria. Expand
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This study characterize a cls mutant in Arabidopsis thaliana, which is devoid of CL, and shows that CLS is crucial for correct mitochondrial function and development inArabidopsis under both optimal and stress conditions. Expand
Schizosaccharomyces pombe cardiolipin synthase is part of a mitochondrial fusion protein regulated by intron retention.
Cardiolipin (CL) is a unique lipid component of mitochondria in all eukaryotes. It is important for the architecture of mitochondrial membranes and for mitochondrial dynamics. CL also creates aExpand
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TLDR
These studies showed that cardiolipin is not only important for mitochondrial ultrastructure and for the stability of respiratory complexes, but it is also a key player in the response to stress, the formation of reactive oxygen species, and the execution of programmed cell death. Expand
Molecular species composition of plant cardiolipin determined by liquid chromatography mass spectrometry
TLDR
During phosphate deprivation or exposure to an extended dark period, the amount of CL decreased in Arabidopsis, accompanied with an increased degree in unsaturation, suggesting the mechanism of CL remodeling during stress, and the function of highly unsaturated CL molecular species, remains to be defined. Expand
Cardiolipin Molecular Species with Shorter Acyl Chains Accumulate in Saccharomyces cerevisiae Mutants Lacking the Acyl Coenzyme A-binding Protein Acb1p
TLDR
The present study aims at a better understanding of the way the CL species profile is established in Saccharomyces cerevisiae by using depletion of the acyl-CoA-binding protein Acb1p as a tool to modulate the cellular acyl chain content. Expand
Cardiolipin-Mediated Mitochondrial Dynamics and Stress Response in Arabidopsis[C][W]
TLDR
This work reveals aspects of the properties and function of the phospholipid cardiolipin (CL) and uncovered conserved and plant-specific aspects of CL biology in mitochondrial dynamics and the organism response to environmental stresses. Expand
Cardiolipin synthesis for the assembly of bacterial and mitochondrial membranes.
  • M. Schlame
  • Biology, Medicine
  • Journal of lipid research
  • 2008
TLDR
It is shown that mitochondria produce cardiolipin species with a high degree of structural uniformity and molecular symmetry, among which there is often a dominant form with four identical acyl chains. Expand
Mammalian cardiolipin biosynthesis.
TLDR
Some of the more recent studies on mammalian cardiolipin biosynthesis are described and the important role that this key phospholipid plays in disease processes including heart failure, diabetes, thyroid hormone disease and the genetic disease Barth Syndrome are discussed. Expand
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Identification of an Arabidopsis thaliana gene for cardiolipin synthase located in mitochondria
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TLDR
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TLDR
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TLDR
Cardiolipin (CL) synthase activity was characterized in mitochondrial extracts of the yeast Saccharomyces cerevisiae and was shown for the first time to utilize CDP-diacylglycerol as a substrate and the enzymatic synthesis of 32P-labelled substrates are described. Expand
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TLDR
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TLDR
It is concluded that yeast CL synthase is a 28-kDa protein, which forms an oligomeric complex whose biogenesis and/or activity is influenced by the assembly of cytochrome oxidase. Expand
Arabidopsis phosphatidylglycerophosphate synthase 1 is essential for chloroplast differentiation, but is dispensable for mitochondrial function.
Genetic dissection of the lipid bilayer composition provides essential in vivo evidence for the role of individual lipid species in membrane function. To understand the in vivo role of the anionicExpand
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