Cardiolipin requirement for electron transfer in complex I and III of the mitochondrial respiratory chain.

@article{Fry1981CardiolipinRF,
  title={Cardiolipin requirement for electron transfer in complex I and III of the mitochondrial respiratory chain.},
  author={M S Fry and David Green},
  journal={The Journal of biological chemistry},
  year={1981},
  volume={256 4},
  pages={
          1874-80
        }
}
Almost complete phospholipid depletion has been achieved for Complex I and III of the mitochondrial respiratory chain using a technique that involves elution on Sephadex LH-20 in the presence of Triton X-100. Enzymic activity may be regenerated by replenishment with phospholipid. However, restoration of enzymic activity in phospholipid-depleted Complex I and III has been shown to require the presence of cardiolipin. These results are, therefore, similar to findings on the absolute catalytic… CONTINUE READING
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