Cardiolipin oxidation sets cytochrome c free

@article{Orrenius2005CardiolipinOS,
  title={Cardiolipin oxidation sets cytochrome c free},
  author={Sten Orrenius and Boris Zhivotovsky},
  journal={Nature Chemical Biology},
  year={2005},
  volume={1},
  pages={188-189}
}
Cytochrome c release from the mitochondria is a critical component of the apoptotic cell-death program. Cytochrome c–catalyzed peroxidation of cardiolipin, a mitochondrial phospholipid, has now been shown to lessen the binding of cytochrome c to the mitochondrial inner membrane and facilitate permeabilization of the outer membrane. These results describe a new and earlier pro-apoptotic role for cytochrome c. 

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Cardiolipin plays a role in KCN-induced necrosis.

Cardiolipin at the heart of stress response across kingdoms

These studies showed that cardiolipin is not only important for mitochondrial ultrastructure and for the stability of respiratory complexes, but it is also a key player in the response to stress, the formation of reactive oxygen species, and the execution of programmed cell death.
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