Cardiolipin-enriched raft-like microdomains are essential activating platforms for apoptotic signals on mitochondria.

@article{Sorice2009CardiolipinenrichedRM,
  title={Cardiolipin-enriched raft-like microdomains are essential activating platforms for apoptotic signals on mitochondria.},
  author={Maurizio Sorice and Valeria Manganelli and P. Matarrese and Antonella Tinari and Roberta Misasi and Walter Malorni and Tina Garofalo},
  journal={FEBS letters},
  year={2009},
  volume={583 15},
  pages={2447-50}
}
Cardiolipin (CL) has recently been shown to provide an anchor and an essential activating platform for caspase-8 on mitochondria. We hypothesize that these platforms may correspond to "raft-like" microdomains, which have demonstrated to be detectable on mitochondrial membrane of cells undergoing apoptosis. The role for CL in "raft-like" microdomains could be to anchor caspase-8 at contact sites between inner and outer membranes, facilitating its self-activation, Bid cleavage and apoptosis… CONTINUE READING