Cardiolipin and the Nlrp3 inflammasome.

@article{ONeill2013CardiolipinAT,
  title={Cardiolipin and the Nlrp3 inflammasome.},
  author={Luke A J O'Neill},
  journal={Cell metabolism},
  year={2013},
  volume={18 5},
  pages={
          610-2
        }
}
The Nlrp3 inflammasome is a key controller of the proinflammatory cytokine IL-1β. Iyer and colleagues (2013) demonstrate that Nlrp3 activators promote an interaction between cardiolipin in mitochondria and Nlrp3. Cardiolipin is thus a hydrophobic danger signal that, upon translocation to the outer mitochondrial membrane, activates Nlrp3, promoting inflammation. 

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