Cardiohemodynamic effects of cromakalim and pinacidil, potassium-channel openers, in the dog, special reference to venous return

Abstract

The cardiohemodynamic effects of the potassium-channel openers, cromakalim and pinacidil, were studied by the use of the closed-loop method (for both drugs) and the cardiopulmonary bypass technique (for cromakalim only) in anesthetized, open-chest dogs. In closed-loop preparations, both drugs (cromakalim, 3 to 100 μg/kg; pinacidil, 10 to 300 μg/kg… (More)
DOI: 10.1007/BF01865509

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Cite this paper

@article{Gotanda1989CardiohemodynamicEO, title={Cardiohemodynamic effects of cromakalim and pinacidil, potassium-channel openers, in the dog, special reference to venous return}, author={Kotaro Gotanda and Hitoshi Yokoyama and Keisuke Satoh and Norio Taira}, journal={Cardiovascular Drugs and Therapy}, year={1989}, volume={3}, pages={507-515} }