Cardio-protective determinants are conserved in aged human myocardium after ischemic preconditioning.

@article{Bartling2003CardioprotectiveDA,
  title={Cardio-protective determinants are conserved in aged human myocardium after ischemic preconditioning.},
  author={Babett Bartling and Claas Hilgefort and Ivar Friedrich and Rolf Edgar Silber and Andreas Simm},
  journal={FEBS letters},
  year={2003},
  volume={555 3},
  pages={
          539-44
        }
}
Ischemic preconditioning (IPrec) improves post-ischemic dysfunctions of the myocardium along with activation of protein kinase C isozymes including PKCdelta. Moreover, expression of cardio-protective determinants can reduce ischemic damages. Because IPrec is limited in aged hearts, we assessed in an experimental model the impact of aging on PKCdelta and selected protective proteins in the preconditioned myocardium from adult (< or =55) and older (> or =70 years) humans. Adult myocardium showed… CONTINUE READING

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