Cardinal Epigenetic Role of non-coding Regulatory RNAs in Circadian Rhythm

  title={Cardinal Epigenetic Role of non-coding Regulatory RNAs in Circadian Rhythm},
  author={Utpal Bhadra and Pradipta Patra and Manika Pal-Bhadra},
  journal={Molecular Neurobiology},
Circadian rhythm which governs basic physiological activities like sleeping, feeding and energy consumption is regulated by light-controlled central clock genes in the pacemaker neuron. The timekeeping machinery with unique transcriptional and post-transcriptional feedback loops is controlled by different small regulatory RNAs in the brain. Roles of the multiple neuronal genes, especially post-transcriptional regulation, splicing, polyadenylation, mature mRNA editing, and stability of… 
Non-coding Vibration in Circadian Oscillation
The basic role of small regulatory RNA and their epigenetic circuits in brain clock activity are summed up.
Extracellular Vesicles: Potential Participants in Circadian Rhythm Synchronization
The current knowledge of CRs, TTFLs, and EVs is summarized, research findings about the functions of EVs in the CR system are examined, and issues requiring attention in future research are discussed.
The Clock-Controlled lncRNA-AK028245 Participates in the Immune Response via Immune Response Factors OTUD7B and A20
The identification of a Clock-regulated lncRNA, AK028245, which was correlated with the activation of the immune response and provided new targets for the treatment of immune disorders is revealed.
Recent Progress in Non-motor Features of Parkinson's Disease with a Focus on Circadian Rhythm Dysregulation.
This review highlights recent research progress on the altered circadian rhythm in PD, ranging from clinical features to the possible causes of PD-related circadian disorders, and believes that future comprehensive studies on the topic may help explore the mechanisms of PD and shed light on the better management of PD.


Post-transcriptional control of circadian rhythms
An overview of current knowledge of post-transcriptional regulation of the clock genes and clock-controlled genes in dinoflagellates, plants, fungi and animals is provided.
Emerging roles for post-transcriptional regulation in circadian clocks
It is hypothesize that post-transcriptional control confers on circadian clocks enhanced robustness as well as the ability to adapt to different environments.
Circadian Genomics Reveal a Role for Post-transcriptional Regulation in Mammals
How circadian genomics have revealed new insights into rhythmic post-transcriptional regulation in mammals is summarized and potential implications of such regulation in controlling many circadian-driven physiologies are discussed.
microRNA Modulation of Circadian-Clock Period and Entrainment
Circadian rhythms and post-transcriptional regulation in higher plants
The circadian clock of plants allows them to cope with daily changes in their environment by the rhythmic regulation of gene expression, in a process that involves many regulatory steps.
Deep sequencing the circadian and diurnal transcriptome of Drosophila brain.
These studies demonstrate extensive circadian control of ncRNA expression, reveal the extent of clock control of alternative splicing and RNA editing, and provide a novel, genome-wide map of splicing in Drosophila brain.
Alternative splicing adds a new loop to the circadian clock
It is concluded that alternative precursor messenger RNA (pre-mRNA) splicing is part of the circadian program and could be a main actor in the fine-tuning of biological clocks.
Circadian and feeding rhythms differentially affect rhythmic mRNA transcription and translation in mouse liver
It is found that rhythmic transcription predominantly drives rhythmic mRNA accumulation and translation for a majority of genes, while increased translation efficiency of 5′-TOP and TISU genes is mainly driven by feeding rhythms but Bmal1 deletion also affects amplitude and phase of translation, including T ISU genes.
RNA around the clock – regulation at the RNA level in biological timing
An update on molecular events at the RNA level that contribute to the 24-h rhythm of the core clock proteins and shape the circadian transcriptome of the model plant Arabidopsis thaliana is provided.
MicroRNA-mediated regulation in the mammalian circadian rhythm.