Cardiac xenotransplantation technology provides materials for improved bioprosthetic heart valves.


OBJECTIVES Human subjects and Old World primates have high levels of antibody to galactose-α-1,3 galactose β-1,4-N-acetylglucosamine (α-Gal). Commercially available bioprosthetic heart valves of porcine and bovine origin retain the Gal antigen despite current processing techniques. Gal-deficient pigs eliminate this xenoantigen. This study tests whether… (More)
DOI: 10.1016/j.jtcvs.2010.08.064