Cardiac vulnerability to ischemia/reperfusion injury drastically increases in late pregnancy

  title={Cardiac vulnerability to ischemia/reperfusion injury drastically increases in late pregnancy},
  author={Jingyuan Li and Soban Umar and Andrea Iorga and Ji-Youn Youn and Yibin Wang and Vera Regitz-Zagrosek and Hua Cai and Mansoureh Eghbali},
  journal={Basic Research in Cardiology},
Although the murine late pregnant (LP) heart is speculated to be a better functioning heart during physiological conditions, the susceptibility of LP hearts to I/R injury is still unknown. The aims of this study were to investigate the cardiac vulnerability of LP rodents to ischemia/reperfusion (I/R) injury and to explore its underlying mechanisms. In vivo female rat hearts [non-pregnant (NP) or LP] or ex vivo Langendorff-perfused mouse hearts were subjected to I/R. The infarct size was… CONTINUE READING
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