Cardiac vagal tone, a non‐invasive measure of parasympathetic tone, is a clinically relevant tool in Type 1 diabetes mellitus

@article{Brock2017CardiacVT,
  title={Cardiac vagal tone, a non‐invasive measure of parasympathetic tone, is a clinically relevant tool in Type 1 diabetes mellitus},
  author={Christina Brock and Niels Jessen and B Brock and Poul Erik Jakobsen and Troels Krarup Hansen and Jesper Moesgaard Rantanen and Sam Riahi and Y K Dimitrova and Anna Dons-Jensen and Qasim Aziz and A M Drewes and Adam D. Farmer},
  journal={Diabetic Medicine},
  year={2017},
  volume={34},
  pages={1428 - 1434}
}
To compare a novel index of parasympathetic tone, cardiac vagal tone, with established autonomic variables and to test the hypotheses that (1) cardiac vagal tone would be associated with established time and frequency domain measures of heart rate and (2) cardiac vagal tone would be lower in people with Type 1 diabetes than in a matched healthy cohort and lower still in people with established neuropathy. 
Gastrointestinal symptoms and cardiac vagal tone in type 1 diabetes correlates with gut transit times and motility index
  • A. Wegeberg, C. Brock, A. Farmer
  • Medicine
    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • 2020
TLDR
The aim was to investigate whether GI symptoms correlate with changes in segmental transit times, segmental motility index, cardiac vagal tone, or the presence/absence of peripheral neuropathy in type 1 diabetes.
The Effect of Transcutaneous Vagus Nerve Stimulation in Patients with Polymyalgia Rheumatica
TLDR
Cardiac vagal tone, blood pressure, heart rate, patient-reported outcome, and biochemical changes were assessed and transcutaneous VNS modulates the autonomic nervous system in patients with PMR, but further investigation of t-VNS in PMR patients is warranted.
Circulating Inflammatory Markers Are Inversely Associated with Heart Rate Variability Measures in Type 1 Diabetes
TLDR
The results show that several pro- and anti-inflammatory factors, believed to be involved in the progression of diabetic polyneuropathy, are associated with cardiovascular autonomic neuropathy, suggesting that these factors may also contribute to the pathogenesis of cardiovascular autonomics neuropathy.
Regional gastrointestinal pH profile is altered in patients with type 1 diabetes and peripheral neuropathy
  • A. Wegeberg, C. Brock, S. Scott
  • Medicine
    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • 2018
TLDR
It is hypothesized that regional pH profiles in T1DM differs from health and would be associated with objective physiological/clinical markers.
Preliminary report: parasympathetic tone links to functional brain networks during the anticipation and experience of visceral pain
TLDR
Findings suggest that PNS tone is associated with functional brain networks during the anticipation and experience of visceral pain, which may represent a potential neurobiological explanation for the anti-nociceptive effect of the PNS.
Morphology of subcortical brain nuclei is associated with autonomic function in healthy humans
TLDR
Novel evidence is provided that resting autonomic state is associated with differences in the shape and volume of subcortical nuclei, which may partly be attributable to perturbation in autonomic function.
Increased levels of inflammatory factors are associated with severity of polyneuropathy in type 1 diabetes
TLDR
The circulating levels of inflammatory markers in individuals with type 1 diabetes with and without DSPN were investigated to determine to what extent these factors correlated with different peripheral sensory nerve functions.
Different Heart Rate Patterns During Cardio-Pulmonary Exercise (CPX) Testing in Individuals With Type 1 Diabetes
TLDR
Using submaximal markers to prescribe exercise intensity in people with T1D, as the heart rate at thresholds is influenced by kHR, is suggested.
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References

SHOWING 1-10 OF 33 REFERENCES
Normal values and reproducibility of the real-time index of vagal tone in healthy humans: a multi-center study
TLDR
In healthy subjects, the normal range for CVT should be considered to be 1.9-17.8 LVS and CVT reproducibility over 1 year, as indexed by an intra-class correlational coefficient of 0.81, was good.
A simple test for autonomic neuropathy in juvenile diabetics.
TLDR
The reproducibility of a simple method for determining the beat-to-beat variation during maximal respiration, using an ordinary ECG apparatus and a ruler, was reproduced and it was found to be independent of a 25-minute period of rest.
A linear scale for measuring vagal tone in man.
  • P. Julu
  • Medicine
    Journal of autonomic pharmacology
  • 1992
TLDR
It was concluded that vagal tone could be selectively measured in an intact person using these simplified and fast algorithms for quantifying respiratory sinus arrhythmia or beat-to-beat variation.
Heart rate independent QT variability component can detect subclinical cardiac autonomic neuropathy in diabetes
TLDR
The proposed measure for quantifying the QTV component independent of HR denoted as QTV~RR stands out to be more discriminatory than other existing variability measures of QTV and HRV in subclinical detection of CAN.
Diabetic Cardiovascular Autonomic Neuropathy
TLDR
The present report discusses the clinical manifestations (eg, resting tachycardia, orthostasis, exercise intolerance, intraoperative cardiovascular liability, silent myocardial infarction [MI], and increased risk of mortality), and demonstrates that autonomic dysfunction can affect daily activities of individuals with diabetes and may invoke potentially life-threatening outcomes.
Power spectral analysis of heart rate variability: a noninvasive signature of cardiac autonomic function.
TLDR
This paper reviews the literature on the methodological issues relevant to signal processing, computational, and clinical applications of PS/HRV and hopes that this review serves as a source of integrated information for researchers in this field.
Influence of Cigarette Smoking on Human Autonomic Function
TLDR
In habitual smokers, smoking acutely reduces baseline levels of vagal- Cardiac nerve activity and completely resets vagally mediated arterial baroreceptor-cardiac reflex responses, likely to influence smokers' responses to acute arterial pressure reductions.
Diabetes and cardiac autonomic neuropathy: Clinical manifestations, cardiovascular consequences, diagnosis and treatment.
TLDR
Medical therapies, including aldose reductase inhibitors, angiotensin-converting enzyme inhibitors, prostoglandin analogs and alpha-lipoic acid, have been found to be effective in randomized controlled trials.
Heart rate variability: origins, methods, and interpretive caveats.
Components of heart rate variability have attracted considerable attention in psychology and medicine and have become important dependent measures in psychophysiology and behavioral medicine.
Cardiac autonomic neuropathy risk estimated by sudomotor function and arterial stiffness in Chinese subjects
TLDR
Cardiac autonomic dysfunction estimated by sudomotor function was correlated with arterial stiffness independent of conventional factors and glucose tolerance status.
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