Cardiac troponin T isoforms affect the Ca(2+) sensitivity of force development in the presence of slow skeletal troponin I: insights into the role of troponin T isoforms in the fetal heart.

@article{Gomes2004CardiacTT,
  title={Cardiac troponin T isoforms affect the Ca(2+) sensitivity of force development in the presence of slow skeletal troponin I: insights into the role of troponin T isoforms in the fetal heart.},
  author={Aldrin V Gomes and Gayathri Venkatraman and Jonathan P. Davis and Svetlana B. Tikunova and Patti L Engel and R. John Solaro and James D. Potter},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 48},
  pages={49579-87}
}
In this study we investigated the physiological role of the cardiac troponin T (cTnT) isoforms in the presence of human slow skeletal troponin I (ssTnI). ssTnI is the main troponin I isoform in the fetal human heart. In reconstituted fibers containing the cTnT isoforms in the presence of ssTnI, cTnT1-containing fibers showed increased Ca(2+) sensitivity of… CONTINUE READING