Cardiac troponin T is essential in sarcomere assembly and cardiac contractility

  title={Cardiac troponin T is essential in sarcomere assembly and cardiac contractility},
  author={Amy J. Sehnert and Anja Huq and Brant M Weinstein and Charline Walker and Mark Fishman and Didier Y. R. Stainier},
  journal={Nature Genetics},
Mutations of the gene (TNNT2) encoding the thin-filament contractile protein cardiac troponin T are responsible for 15% of all cases of familial hypertrophic cardiomyopathy, the leading cause of sudden death in young athletes. Mutant proteins are thought to act through a dominant-negative mode that impairs function of heart muscle. TNNT2 mutations can also lead to dilated cardiomyopathy, a leading cause of heart failure. Despite the importance of cardiac troponin T in human disease, its loss-of… CONTINUE READING
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