Cardiac transplant experience with cyclosporine.

@article{Patel2004CardiacTE,
  title={Cardiac transplant experience with cyclosporine.},
  author={Julie Patel and Jon Kobashigawa},
  journal={Transplantation proceedings},
  year={2004},
  volume={36 2 Suppl},
  pages={323S-330S}
}
The advent of cyclosporine 20 years ago was a major advance in the field of solid organ transplantation. Its use enabled directed immunosuppression with a consequent decrease in the incidence of graft failure, acute rejection, and systemic infection. The early oil-based preparation, however, was difficult to administer and had limited bioavailability and unpredictable pharmacokinetics. The drug also has a fairly narrow therapeutic window with major long-term side effects, which include… CONTINUE READING

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