Cardiac transcriptional response to acute and chronic angiotensin II treatments.

@article{Larkin2004CardiacTR,
  title={Cardiac transcriptional response to acute and chronic angiotensin II treatments.},
  author={Jennie Larkin and Bryan C. Frank and Renee M Gaspard and Irena Duka and Haralambos Gavras and John Quackenbush},
  journal={Physiological genomics},
  year={2004},
  volume={18 2},
  pages={152-66}
}
Exposure of experimental animals to increased angiotensin II (ANG II) induces hypertension associated with cardiac hypertrophy, inflammation, and myocardial necrosis and fibrosis. Some of the most effective antihypertensive treatments are those that antagonize ANG II. We investigated cardiac gene expression in response to acute (24 h) and chronic (14 day) infusion of ANG II in mice; 24-h treatment induces hypertension, and 14-day treatment induces hypertension and extensive cardiac hypertrophy… CONTINUE READING

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