Cardiac synthesis, processing, and coronary release of enkephalin-related peptides.

@article{Youns2000CardiacSP,
  title={Cardiac synthesis, processing, and coronary release of enkephalin-related peptides.},
  author={A. Youn{\`e}s and S. Pepe and B. Barron and H. Spurgeon and E. Lakatta and J. Caffrey},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2000},
  volume={279 4},
  pages={
          H1989-98
        }
}
Although preproenkephalin mRNA is abundant in the heart, the myocardial synthesis and processing of proenkephalin is largely undefined. Isolated working rat hearts were perfused to determine the rate of myocardial proenkephalin synthesis, its processing into enkephalin-containing peptides, their subsequent release into the coronary arteries, and the influence of prior sympathectomy. Enkephalin-containing peptides were separated by gel filtration and quantified with antisera for specific COOH… Expand
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