Cardiac sympathetic denervation correlates with clinical and pathologic stages of Parkinson's disease.

@article{Fujishiro2008CardiacSD,
  title={Cardiac sympathetic denervation correlates with clinical and pathologic stages of Parkinson's disease.},
  author={Hiroshige Fujishiro and Roberta Frigerio and Melinda Burnett and Kevin J. Klos and Keith A. Josephs and Anthony Delledonne and Joseph E. Parisi and J. Eric Ahlskog and Dennis W. Dickson},
  journal={Movement disorders : official journal of the Movement Disorder Society},
  year={2008},
  volume={23 8},
  pages={1085-92}
}
Attention has been drawn to cardiac sympathetic denervation in Parkinson's disease (PD) based on clinical studies using [123I] metaiodobenzylguanidine scintigraphy; however, the histologic correlates and time course of cardiac sympathetic denervation are poorly understood. To address these issues, we used tyrosine hydroxylase (TH) immunohistochemistry to detect cardiac sympathetic nerve fibers in the epicardium of 4 normal controls, 11 cases with incidental Lewy bodies (iLBs), and 14 cases of… CONTINUE READING