Cardiac surgery increases the activity of matrix metalloproteinases and nitric oxide synthase in human hearts.

@article{Mayers2001CardiacSI,
  title={Cardiac surgery increases the activity of matrix metalloproteinases and nitric oxide synthase in human hearts.},
  author={Irvin Mayers and Thomas Hurst and Lakshmi Puttagunta and Anna Radomski and Taras R Mycyk and Grzegorz Sawicki and David Johnson and Marek Witold Radomski},
  journal={The Journal of thoracic and cardiovascular surgery},
  year={2001},
  volume={122 4},
  pages={746-52}
}
OBJECTIVES Heart function is variably impaired after cardiopulmonary bypass. We hypothesized that, similar to other myocardial injury states, cardiopulmonary bypass leads to enhanced activity of nitric oxide synthase and matrix metalloproteinases. METHODS We obtained right atrial biopsy specimens and plasma samples at the onset and termination of cardiopulmonary bypass in 10 patients. Biopsy specimens were analyzed for nitric oxide synthase activity by using a citrulline assay, whereas plasma… CONTINUE READING
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