Cardiac steroidogenesis in the normal and failing heart.

@article{Young2001CardiacSI,
  title={Cardiac steroidogenesis in the normal and failing heart.},
  author={Morag J. Young and Colin Clyne and Tim James Cole and John W. Funder},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2001},
  volume={86 11},
  pages={5121-6}
}
The present study explores the possibility of local de novo aldosterone production in normal and failing hearts (human and mouse) and the regulation of such putative cardiac steroidogenesis. Total RNA was isolated from human tissue from failing hearts taken at the time of cardiac transplantation, from normal hearts obtained at autopsy, and from normal and pressure-overloaded mouse hearts. Vascular smooth muscle cells from human artery and vein were also analyzed. RNA was reverse transcribed and… CONTINUE READING

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Editorial: Cardiac steroidogenesis--new sites of synthesis, or much ado about nothing?

The Journal of clinical endocrinology and metabolism • 2001
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References

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Steroidogenic enzyme gene expression in the human heart.

The Journal of clinical endocrinology and metabolism • 2000
View 5 Excerpts
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Regulation of aldosterone synthase in human vascular endothelial cells by angiotensin II and adrenocorticotropin.

The Journal of clinical endocrinology and metabolism • 1996
View 10 Excerpts
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