Cardiac stem cells possess growth factor-receptor systems that after activation regenerate the infarcted myocardium, improving ventricular function and long-term survival.

@article{Urbanek2005CardiacSC,
  title={Cardiac stem cells possess growth factor-receptor systems that after activation regenerate the infarcted myocardium, improving ventricular function and long-term survival.},
  author={Konrad Urbanek and Marcello Rota and Stefano Cascapera and Claudia Bearzi and Angelo Nascimbene and Antonella De Angelis and Toru Hosoda and Stefano Chimenti and Mathue Baker and Federica Limana and Daria Nurzynska and Daniele Torella and Francesco Rotatori and Raffaella Rastaldo and Ezio Musso and Federico Quaini and Annarosa Leri and Jan Kajstura and Piero Anversa},
  journal={Circulation research},
  year={2005},
  volume={97 7},
  pages={663-73}
}
Cardiac stem cells and early committed cells (CSCs-ECCs) express c-Met and insulin-like growth factor-1 (IGF-1) receptors and synthesize and secrete the corresponding ligands, hepatocyte growth factor (HGF) and IGF-1. HGF mobilizes CSCs-ECCs and IGF-1 promotes their survival and proliferation. Therefore, HGF and IGF-1 were injected in the hearts of infarcted mice to favor, respectively, the translocation of CSCs-ECCs from the surrounding myocardium to the dead tissue and the viability and… CONTINUE READING
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Cellular basis of physiological and pathological myocardial growth

  • P. Anversa, G. Olivetti
  • Handbook of Physiology. The Cardiovascular System…
  • 2002

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