Cardiac-specific troponin I levels to predict the risk of mortality in patients with acute coronary syndromes.

@article{Antman1996CardiacspecificTI,
  title={Cardiac-specific troponin I levels to predict the risk of mortality in patients with acute coronary syndromes.},
  author={Elliott Marshall Antman and Milenko Tanasijevic and Bruce Thompson and Mark Schactman and Colm McCabe and Christopher P. Cannon and George A. Fischer and Anthony Y. Fung and C Thompson and Donald R. Wybenga and Eugene Braunwald},
  journal={The New England journal of medicine},
  year={1996},
  volume={335 18},
  pages={
          1342-9
        }
}
BACKGROUND In patients with acute coronary syndromes, it is desirable to identify a sensitive serum marker that is closely related to the degree of myocardial damage, provides prognostic information, and can be measured rapidly. We studied the prognostic value of cardiac troponin I levels in patients with unstable angina or non-Q-wave myocardial infarction. METHODS In a multicenter study, blood specimens from 1404 symptomatic patients were analyzed for cardiac troponin I, a serum marker not… 
Troponin T levels in patients with acute coronary syndromes, with or without renal dysfunction.
TLDR
Cardiac troponin T levels predict short-term prognosis in patients with acute coronary syndromes regardless of their level of creatinine clearance, and was independently predictive of risk across the entire spectrum of renal function.
Applicability of cardiac troponin T and I for early risk stratification in unstable coronary artery disease. TRIM Study Group. Thrombin Inhibition in Myocardial ischemia.
TLDR
In patients suspected of having unstable coronary artery disease, both troponin T and Troponin I provide independent prognostic information with regard to cardiac death and acute myocardial infarction.
Elevated cardiac troponin levels predict the risk of adverse outcome in patients with acute coronary syndromes.
TLDR
Patients with acute coronary syndromes who have troponin elevations show a substantial increase in risk during short and long-term follow-up, which was maintained long term.
The role of cardiac Troponin‐I (cTnI) in risk stratification of patients with unstable coronary artery disease
TLDR
The presence of elevated cTnI in serum is a significant prognostic indicator in patients with unstable angina and non‐Q wave MI and its independent prognostic potential persists even after adjustment for independent baseline variables known to be significantly associated with an increased risk of cardiac events.
Comparison of the prognostic value of C-reactive protein and troponin I in patients with unstable angina pectoris.
TLDR
Both in unselected patients with unstable angina and in patients with angiographically proven coronary artery disease, increased cTnI within 24 hours of admission, but not CRP, is a predictor of in-hospital clinical outcome.
A sensitive cardiac troponin T assay in stable coronary artery disease.
TLDR
Cardiac troponin T concentrations as measured with a highly sensitive assay were significantly associated with the incidence of cardiovascular death and heart failure but not with myocardial infarction in patients with stable coronary artery disease.
Coronary angiographic findings in patients with clinical unstable angina according to cardiac troponin I and T concentrations in serum.
TLDR
Patients with unstable angina who have significant release of cardiac troponin I and/or cTnT have evidence of more complex lesions on coronary angiography, supporting the hypothesis that both troponins might be used without distinction as surrogate markers for microembolization from thrombus formation on a disrupted plaque.
Prognostic value of low-level cardiac troponin-I elevations in patients without definite acute coronary syndromes
TLDR
Low-level cTn-I elevations identify a subset of patients at increased risk for future cardiovascular events, even when obtained outside the context of definite ACS or presentation with chest pain.
Acute Ischemic Heart Disease Prognostic value of low-level cardiac troponin-I elevations in patients without definite acute coronary syndromes
TLDR
Low-level cardiac troponin-I elevations identify a subset of patients at increased risk for future cardiovascular events, even when obtained outside the context of definite ACS or presentation with chest pain.
High-sensitivity cardiac troponin for risk prediction in patients with and without coronary heart disease.
TLDR
The use of hsTnT in addition to clinical variables significantly improves discrimination and reclassification of patients with respect to all-cause mortality or non-fatal myocardial infarction irrespective of the presence of clinically detectable coronary heart disease.
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