Cardiac-specific overexpression of phospholamban alters calcium kinetics and resultant cardiomyocyte mechanics in transgenic mice.

@article{Kadambi1996CardiacspecificOO,
  title={Cardiac-specific overexpression of phospholamban alters calcium kinetics and resultant cardiomyocyte mechanics in transgenic mice.},
  author={Vivek J. Kadambi and Sathivel Ponniah and Judy M. Harrer and Brian D. Hoit and Gerald W. Dorn and R. W. Smith A. Walsh and Evangelia G Kranias},
  journal={The Journal of clinical investigation},
  year={1996},
  volume={97 2},
  pages={533-9}
}
Phospholamban is the regulator of the cardiac sarcoplasmic reticulum (SR) Ca(2+)-ATPase activity and an important modulator of basal contractility in the heart. To determine whether all the SR Ca(2+)-ATPase enzymes are subject to regulation by phospholamban in vivo, transgenic mice were generated which overexpressed phospholamban in the heart, driven by the cardiac-specific alpha-myosin heavy chain promoter. Quantitative immunoblotting revealed a twofold increase in the phospholamban protein… CONTINUE READING

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