Cardiac-specific overexpression of catalase rescues ventricular myocytes from ethanol-induced cardiac contractile defect.

@article{Zhang2003CardiacspecificOO,
  title={Cardiac-specific overexpression of catalase rescues ventricular myocytes from ethanol-induced cardiac contractile defect.},
  author={Xiaochun Zhang and Aaron L. Klein and Nicholas S Alberle and Faye L. Norby and Bonnie H Ren and Jinhong Duan and Jun Ren},
  journal={Journal of molecular and cellular cardiology},
  year={2003},
  volume={35 6},
  pages={645-52}
}
Oxidative stress is intimately involved in alcoholic cardiomyopathy. Catalase is responsible for detoxification of hydrogen peroxide (H(2)O(2)) and may interfere with ethanol-induced cardiac toxicity. To test this hypothesis, a transgenic mouse line was produced to overexpress catalase (~50-fold) in the heart, ranging from sarcoplasm, the nucleus and peroxisomes within myocytes. Mechanical and intracellular Ca(2+) properties were evaluated in ventricular myocytes from catalase transgenic (CAT… CONTINUE READING