Cardiac-specific overexpression of SCN5A gene leads to shorter P wave duration and PR interval in transgenic mice.

@article{Zhang2007CardiacspecificOO,
  title={Cardiac-specific overexpression of SCN5A gene leads to shorter P wave duration and PR interval in transgenic mice.},
  author={Teng Zhang and Sandro L. Yong and Xiaoli Tian and Qing Kenneth Wang},
  journal={Biochemical and biophysical research communications},
  year={2007},
  volume={355 2},
  pages={444-50}
}
The Cardiac sodium channel gene SCN5A plays a critical role in cardiac electrophysiology and its mutations, either gain- or loss-of-functions, are associated with lethal arrhythmias. In this study, we investigated the effect of overexpression of SCN5A on the cardiac phenotype in a transgenic mouse model (TG-WT L10). Compared to NTG mice, heart rate, QRS duration, and QT intervals remained unchanged in TG-WT mice. Moreover, no spontaneous ventricular arrhythmias were detected in TG-WT hearts… CONTINUE READING
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