Cardiac-specific overexpression of GLUT1 prevents the development of heart failure attributable to pressure overload in mice.

@article{Liao2002CardiacspecificOO,
  title={Cardiac-specific overexpression of GLUT1 prevents the development of heart failure attributable to pressure overload in mice.},
  author={Ronglih Liao and Mohit Jain and Lei Cui and Jessica D'Agostino and Francesco Aiello and Ivan Luptak and Soeun Ngoy and Richard M. Mortensen and Rong Tian},
  journal={Circulation},
  year={2002},
  volume={106 16},
  pages={2125-31}
}
BACKGROUND Increased rates of glucose uptake and glycolysis have been repeatedly observed in cardiac hypertrophy and failure. Although these changes have been considered part of the fetal gene reactivation program, the functional significance of increased glucose utilization in hypertrophied and failing myocardium is poorly understood. METHODS AND RESULTS We generated transgenic (TG) mice with cardiac-specific overexpression of insulin-independent glucose transporter GLUT1 to recapitulate the… CONTINUE READING

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Heart Failure: Pathophysiology, Molecular Biology and Clinical Management. Philadelphia, Pa

  • AM Katz
  • 2000

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