Cardiac-specific genetic inhibition of nuclear factor-κB prevents right ventricular hypertrophy induced by monocrotaline.

  title={Cardiac-specific genetic inhibition of nuclear factor-$\kappa$B prevents right ventricular hypertrophy induced by monocrotaline.},
  author={Sandeep Kumar and Chuanyu Wei and Candice Michelle Thomas and Il-Kwon Kim and Rachid Seqqat and Rajesh Kumar and Kenneth M. Baker and Walter Keith Jones and Sudhiranjan Gupta},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={302 8},
Uncontrolled pulmonary arterial hypertension (PAH) results in right ventricular (RV) hypertrophy (RVH), progressive RV failure, and low cardiac output leading to increased morbidity and mortality (McLaughlin VV, Archer SL, Badesch DB, Barst RJ, Farber HW, Lindner JR, Mathier MA, McGoon MD, Park MH, Rosenson RS, Rubin LJ, Tapson VF, Varga J. J Am Coll Cardiol 53: 1573-1619, 2009). Although the exact figures of its prevalence are difficult to obtain because of the diversity of identifiable causes… 

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