Cardiac-specific deletion of mkk4 reveals its role in pathological hypertrophic remodeling but not in physiological cardiac growth.

@article{Liu2009CardiacspecificDO,
  title={Cardiac-specific deletion of mkk4 reveals its role in pathological hypertrophic remodeling but not in physiological cardiac growth.},
  author={Wei Liu and Min Zi and Jiawei Jin and Sukhpal Prehar and Delvac Oceandy and Tomomi E. Kimura and Ming Lei and Ludwig Neyses and Arthur H. Weston and Elizabeth J. Cartwright and Xin Wang},
  journal={Circulation research},
  year={2009},
  volume={104 7},
  pages={905-14}
}
Mitogen-activated protein kinase kinase (MKK)4 is a critical member of the mitogen-activated protein kinase family. It is able to activate the c-Jun NH(2)-terminal protein kinase (JNK) and p38 mitogen-activated protein kinase in response to environmental stresses. JNK and p38 are strongly implicated in pathological cardiac hypertrophy and heart failure; however, the regulatory mechanism whereby the upstream kinase MKK4 activates these signaling cascades in the heart is unknown. To elucidate the… CONTINUE READING

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Mitogen-activated protein kinases in heart development and diseases

  • Y. Wang
  • 2007

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