Cardiac sodium-calcium exchanger is regulated by allosteric calcium and exchanger inhibitory peptide at distinct sites.

@article{Maack2005CardiacSE,
  title={Cardiac sodium-calcium exchanger is regulated by allosteric calcium and exchanger inhibitory peptide at distinct sites.},
  author={Christoph Maack and Anand N Ganesan and Agnieszka Sidor and Brian O'Rourke},
  journal={Circulation research},
  year={2005},
  volume={96 1},
  pages={91-9}
}
The sarcolemmal Na+-Ca2+ exchanger (NCX) is the main Ca2+ extrusion mechanism in cardiac myocytes and is thus essential for the regulation of Ca2+ homeostasis and contractile function. A cytosolic region (f-loop) of the protein mediates regulation of NCX function by intracellular factors including inhibition by exchanger inhibitory peptide (XIP), a 20 amino acid peptide matching the sequence of an autoinhibitory region involved in allosteric regulation of NCX by intracellular Na+, Ca2+, and… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

Palmitoylation of the Na/Ca exchanger cytoplasmic loop controls its inactivation and internalization during stress signaling

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2015

Intracellular Na⁺ and cardiac metabolism.

Journal of molecular and cellular cardiology • 2013
View 1 Excerpt

Similar Papers

Loading similar papers…