Cardiac sensitization thresholds of halon replacement chemicals predicted in humans by physiologically-based pharmacokinetic modeling.

@article{Vinegar1996CardiacST,
  title={Cardiac sensitization thresholds of halon replacement chemicals predicted in humans by physiologically-based pharmacokinetic modeling.},
  author={Allen Vinegar and Gary W Jepson},
  journal={Risk analysis : an official publication of the Society for Risk Analysis},
  year={1996},
  volume={16 4},
  pages={571-9}
}
Human exposure to halons and halon replacement chemicals is often regulated on the basis of cardiac sensitization potential. The dose-response data obtained from animal testing are used to determine the no observable adverse effect level (NOAEL) and lowest observable adverse effect level (LOAEL) values. This approach alone does not provide the information necessary to evaluate the cardiac sensitization potential for the chemical of interest under a variety of exposure concentrations and… CONTINUE READING
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