Cardiac sarcoplasmic reticulum function in insulin- or carnitine-treated diabetic rats.

@article{Lopaschuk1983CardiacSR,
  title={Cardiac sarcoplasmic reticulum function in insulin- or carnitine-treated diabetic rats.},
  author={Gary D Lopaschuk and A G Tahiliani and R V Vadlamudi and Sidney Katz and John Hugh McNeill},
  journal={The American journal of physiology},
  year={1983},
  volume={245 6},
  pages={H969-76}
}
Cardiac sarcoplasmic reticulum (SR) function and SR levels of long-chain (LC) acylcarnitines were determined in streptozotocin-induced diabetic rats treated with insulin or D,L-carnitine. ATP-dependent calcium transport was significantly depressed in cardiac SR isolated from untreated diabetic rats compared with control rats. Diabetic rat cardiac SR levels of LC acylcarnitines were also significantly elevated. Various parameters of heart function (left ventricular developed pressure, +dP/dT… CONTINUE READING

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